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Alexandre Lacazette scored in stoppage time as Lyon came from 2-1 behind to beat Roma in the Europa League last-16.
Mouctar Diakhaby put the French club ahead before Roma hit back through Mohamed Salah and Federico Fazio.
Lyon scored three second-half goals through Corentin Tolisso, Nabil Fekir and Lacazette ahead of next Thursday’s second leg in Rome.
Elsewhere Gent, who beat Tottenham in the last round, lost 5-2 at home to Belgium rivals Genk.
Mbwana Samatta scored twice for Genk while Gent finished the game with 10 men after Anderson Esiti was sent off six minutes from time.
It finished 1-1 in the all-German tie between Schalke and Borussia Monchengladbach, while substitute Claudio Beauvue headed a 90th minute winner for Celta Vigo, who beat Krasnodar 2-1 ahead of the second leg in Russia.
A mistake from Olympiakos keeper Nicola Leali, when he kicked the ball straight to Vincent Aboubakar, cost his side as the Besiktas forward scored to cancel out Esteban Cambiasso’s first-half goal, the tie ending 1-1.
Former Cardiff City striker Andreas Cornelius headed a second-half winner as Danish champions FC Copenhagen beat Ajax 2-1.
Copenhagen made a flying start through Rasmus Falk Jensen inside the first minute. Danish teenager Kasper Dolberg, 19, equalised for Ajax with his 15th goal of the season before Cornelius struck.
Anderlecht won 1-0 in Cyprus against Apoel Nicosia, Nicolae Stanciu hitting the winner.